› 8dw5

X-ray diffraction
1.52Å resolution

Complex of Human Transthyretin with 3',5'-Dichlorophenylanthranilic Acid

Released:
DOI: 10.2210/pdb8dw5/pdb
PDB entry 8dw5 coloured by chain, front view.
PDB entry 8dw5 coloured by chain, side view.
PDB entry 8dw5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Analysis of the Complex of Human Transthyretin with 3',5'-Dichlorophenylanthranilic Acid at 1.5 Å Resolution.
Cody V, Truong JQ, Holdsworth BA, Holien JK, Richardson SJ, Chalmers DK, Craik DJ
OpenAccess logo Molecules 27 (2022)
PMID: 36364032

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chain: A
Molecule details ›
Chain: A
Length: 142 amino acids
Theoretical weight: 15.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 6-6, 21-147; Coverage: 89%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
Ligand FQ7 1 x FQ7
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: I222
Unit cell:
a: 41.198Å b: 64.079Å c: 84.529Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.197 0.235
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Structural Analysis of the Complex of Human Transthyretin with 3',5'-Dichlorophenylanthranilic Acid at 1.5 Å Resolution.
Cody et al. (2022)