› 8dxo

Electron Microscopy
3.6Å resolution

Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 2

Released:
DOI: 10.2210/pdb8dxo/pdb
PDB entry 8dxo coloured by chain, front view.
PDB entry 8dxo coloured by chain, side view.
PDB entry 8dxo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly.
Takahashi H, Yamada T, Denton JS, Strange K, Karakas E
OpenAccess logo Elife 12 (2023)
PMID: 36897307
Related structures: EMD-27771

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184894 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Volume-regulated anion channel subunit LRRC8A; Volume-regulated anion channel subunit LRRC8C Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 825 amino acids
Theoretical weight: 94.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8IWT6 (Residues: 1-6, 182-206; Coverage: 4%)
  • Canonical: Q8TDW0 (Residues: 7-183, 206-803; Coverage: 96%)
Gene names: AD158, FAD158, KIAA1437, LRRC8, LRRC8A, LRRC8C, SWELL1, UNQ221/PRO247
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-27771
Expression system: Spodoptera frugiperda

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Citations

1 review citation

Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC: part 2: its activation mechanisms and essential roles in organic signal release.
Okada Y. (2024)
3 other articles