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Crystal Structure of scFv CAT2200 LH in complex with IL-17A

X-ray diffraction
2.68Å resolution
PDB entry 8dy1 coloured by chain, front view.
PDB entry 8dy1 coloured by chain, side view.
PDB entry 8dy1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interleukin-17A and IG-light lambda chain and IG-light lambda chain
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Multimeric state: hetero dimer
Accessible surface area: 16651.06 Å2
Buried surface area: 1541.23 Å2
Dissociation area: 614.64 Å2
Dissociation energy (ΔGdiss): 6.57 kcal/mol
Dissociation entropy (TΔSdiss): 11.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-280174
Assembly 2
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Assembly Name: Interleukin-17A and IG-light lambda chain and IG-light lambda chain
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Multimeric state: hetero dimer
Accessible surface area: 15937.71 Å2
Buried surface area: 1589.54 Å2
Dissociation area: 640.19 Å2
Dissociation energy (ΔGdiss): 5.76 kcal/mol
Dissociation entropy (TΔSdiss): 11.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-280174

Macromolecules

Interleukin-17A
Chains: A, B
Length: 122 amino acids
Theoretical weight: 14.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16552 (Residues: 35-155; Coverage: 92%)
Gene names: CTLA8, IL17, IL17A
Pfam: Interleukin-17
Interleukin-17A in PDB entry 8dy1, assembly 1, front view.
Interleukin-17A in PDB entry 8dy1, assembly 1, side view.
Interleukin-17A in PDB entry 8dy1, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q16552  
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scFv CAT2200 LH
Chains: C, D
Length: 255 amino acids
Theoretical weight: 26.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
scFv CAT2200 LH in PDB entry 8dy1, assembly 1, front view.
scFv CAT2200 LH in PDB entry 8dy1, assembly 1, side view.
scFv CAT2200 LH in PDB entry 8dy1, assembly 1, top view.
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