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Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography.

Dickmann CGF, McDonald AF, Huynh N, Rigopoulos A, Liu Z, Guo N, Osellame LD, Gorman MA, Parker MW, Gan HK, Scott AM, Ackermann U, Burvenich IJG, White JM
Chem Commun (Camb) 59 3126-3129 (2023)
Related entries: 8dyr, 8e3w

Cited: 1 times
EuropePMC logo PMID: 36809538

Abstract

Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Here, we report the development of a novel molecule radiolabelled with positron emitting fluorine-18, [18F]BiPET-2, and its in vitro and preclinical evaluation in glioblastoma models.

Articles - 8e17 mentioned but not cited (1)

  1. Modal gain characteristics of a two-section InGaAs/GaAs double quantum well passively mode-locked laser with asymmetric waveguide. Qiao Z, Li X, Sia JXB, Wang W, Wang H, Li Z, Zhao Z, Li L, Gao X, Bo B, Qu Y, Liu G, Liu C. Sci Rep 12 5010 (2022)




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