8e1p

X-ray diffraction
3.82Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
PDBe Complex ID:
PDB-CPX-274334 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (13 distinct):
germline PGV20 heavy chain Chains: F, H, N
Molecule details ›
Chains: F, H, N
Length: 225 amino acids
Theoretical weight: 24.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
germline PGV20 light chain Chain: I
Molecule details ›
Chain: I
Length: 210 amino acids
Theoretical weight: 22.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
germline PGV20 light chain Chains: L, O
Molecule details ›
Chains: L, O
Length: 210 amino acids
Theoretical weight: 22.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
PGT124 Fab Light Chain Chains: A, C, J
Molecule details ›
Chains: A, C, J
Length: 214 amino acids
Theoretical weight: 23.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
BG505-SOSIP.v4.1-GT1.2gp120 Chains: E, G, M
Molecule details ›
Chains: E, G, M
Length: 474 amino acids
Theoretical weight: 53.39 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
PGT124 Fab Heavy Chain Chains: B, D, K
Molecule details ›
Chains: B, D, K
Length: 236 amino acids
Theoretical weight: 25.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Transmembrane protein gp41 Chains: X, Y, Z
Molecule details ›
Chains: X, Y, Z
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21
Unit cell:
a: 146.057Å b: 157.666Å c: 158.558Å
α: 90° β: 102.973° γ: 90°
R-values:
R R work R free
0.272 0.271 0.301
Expression system: Homo sapiens