› 8e1z

X-ray diffraction
2.3Å resolution

Crystal structure of Plasmodium falciparum ookinete surface antigen Pfs28

Released:
DOI: 10.2210/pdb8e1z/pdb
PDB entry 8e1z coloured by chain, front view.
PDB entry 8e1z coloured by chain, side view.
PDB entry 8e1z coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Structural analysis of Plasmodium falciparum ookinete surface antigen Pfs28 relevant for malaria vaccine design.
Shukla N, Tang WK, Tolia NH
OpenAccess logo Sci Rep 12 19556 (2022)
PMID: 36379968

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179852 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
EGF-like domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 20.34 KDa
Source organism: Plasmodium falciparum
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6LEB4 (Residues: 24-196; Coverage: 88%)
Sequence domains: Pvs28 EGF domain

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 35.73Å b: 74.18Å c: 69.82Å
α: 90° β: 105.17° γ: 90°
R-values:
R R work R free
0.239 0.235 0.277
Expression system: Homo sapiens

Quick links

Citations

1 review citation

To each its own: Mechanisms of cross-talk between GPI biosynthesis and cAMP-PKA signaling in Candida albicans versus Saccharomyces cerevisiae.
Komath SS. (2024)
2 other articles

1 mention without citation

Diversity and selection analyses identify transmission-blocking antigens as the optimal vaccine candidates in Plasmodium falciparum.
Ciubotariu et al. (2024)