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Cryo-EM structure of the full-length human NF1 dimer

Electron Microscopy
3.6Å resolution
PDB entry 8e20 coloured by chain, front view.
PDB entry 8e20 coloured by chain, side view.
PDB entry 8e20 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neurofibromin truncated
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Multimeric state: homo dimer
Accessible surface area: 220373.32 Å2
Buried surface area: 6215.9 Å2
Dissociation area: 3,107.95 Å2
Dissociation energy (ΔGdiss): 37.7 kcal/mol
Dissociation entropy (TΔSdiss): 18.94 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149214

Macromolecules

Neurofibromin
Chains: A, B
Length: 2818 amino acids
Theoretical weight: 317.41 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21359 (Residues: 1-2839; Coverage: 99%)
  • Best match: P21359-2 (Residues: 1-2818)
Gene name: NF1
Pfam:
InterPro:
Neurofibromin in PDB entry 8e20, assembly 1, front view.
Neurofibromin in PDB entry 8e20, assembly 1, side view.
Neurofibromin in PDB entry 8e20, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P21359  
128182004006008001,0001,2001,4001,6001,8002,0002,2002,4002,6002,800
 
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UniProt
P21359
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