8e28

Electron Microscopy
3.1Å resolution

Human Dis3L2 in complex with hairpin A-GCU14

Released:
Primary publication:
A shape-shifting nuclease unravels structured RNA.
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 36823385
Related structures: EMD-27828

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-184933 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
DIS3-like exonuclease 2 Chain: A
Molecule details ›
Chain: A
Length: 858 amino acids
Theoretical weight: 96.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8IYB7 (Residues: 1-858; Coverage: 97%)
Gene names: DIS3L2, FAM6A
Sequence domains:
RNA hairpin A-GCU14 Chain: C
Molecule details ›
Chain: C
Length: 34 nucleotides
Theoretical weight: 10.68 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.1Å
Relevant EMDB volumes: EMD-27828
Expression systems:
  • Spodoptera frugiperda
  • Not provided