8e2a

Electron Microscopy
2.8Å resolution

Human Dis3L2 in complex with hairpin D-U7

Released:
Primary publication:
A shape-shifting nuclease unravels structured RNA.
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 36823385
Related structures: EMD-27830

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-184935 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
DIS3-like exonuclease 2 Chain: A
Molecule details ›
Chain: A
Length: 885 amino acids
Theoretical weight: 99.41 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8IYB7 (Residues: 1-885; Coverage: 100%)
Gene names: DIS3L2, FAM6A
Sequence domains:
RNA hairpin D-U7 Chain: B
Molecule details ›
Chain: B
Length: 23 nucleotides
Theoretical weight: 7.25 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.8Å
Relevant EMDB volumes: EMD-27830
Expression systems:
  • Spodoptera frugiperda
  • Not provided