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Cryo-EM structure of the VPAC1R-VIP-Gs complex

Source organisms:
Biochemical function: protein binding
Biological process: G protein-coupled receptor signaling pathway
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
The deposited structure of PDB entry 8e3z contains 7 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. Showing 7 copies in chain B.

PF00002
Domain description: 7 transmembrane receptor (Secretin family)
Occurring in:
  1. Vasoactive intestinal polypeptide receptor 1
The deposited structure of PDB entry 8e3z contains 1 copy of Pfam domain PF00002 (7 transmembrane receptor (Secretin family)) in Vasoactive intestinal polypeptide receptor 1. Showing 1 copy in chain F [auth R].

PF02793
Domain description: Hormone receptor domain
Occurring in:
  1. Vasoactive intestinal polypeptide receptor 1
The deposited structure of PDB entry 8e3z contains 1 copy of Pfam domain PF02793 (Hormone receptor domain) in Vasoactive intestinal polypeptide receptor 1. Showing 1 copy in chain F [auth R].

PF00123
Domain description: Peptide hormone
Occurring in:
  1. Vasoactive intestinal peptide
The deposited structure of PDB entry 8e3z contains 1 copy of Pfam domain PF00123 (Peptide hormone) in Vasoactive intestinal peptide. Showing 1 copy in chain E [auth P].

PF00631
Domain description: GGL domain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
The deposited structure of PDB entry 8e3z contains 1 copy of Pfam domain PF00631 (GGL domain) in Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2. Showing 1 copy in chain C [auth G].

PF00503
Domain description: G-protein alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 8e3z contains 1 copy of Pfam domain PF00503 (G-protein alpha subunit) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR001019
Domain description: Guanine nucleotide binding protein (G-protein), alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR000832
Domain description: GPCR, family 2, secretin-like
Occurring in:
  1. Vasoactive intestinal polypeptide receptor 1
IPR001771
Domain description: GPCR, family 2, vasoactive intestinal peptide receptor 1
Occurring in:
  1. Vasoactive intestinal polypeptide receptor 1
IPR000367
Domain description: G-protein alpha subunit, group S
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR001571
Domain description: GPCR, family 2, vasoactive intestinal peptide receptor
Occurring in:
  1. Vasoactive intestinal polypeptide receptor 1
IPR015898
Domain description: G-protein gamma-like domain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR001770
Domain description: G-protein, gamma subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR001632
Domain description: G-protein, beta subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR001879
Domain description: GPCR, family 2, extracellular hormone receptor domain
Occurring in:
  1. Vasoactive intestinal polypeptide receptor 1
IPR000532
Domain description: Glucagon/GIP/secretin/VIP
Occurring in:
  1. Vasoactive intestinal peptide
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR017983
Domain description: GPCR, family 2, secretin-like, conserved site
Occurring in:
  1. Vasoactive intestinal polypeptide receptor 1
IPR036445
Domain description: GPCR family 2, extracellular hormone receptor domain superfamily
Occurring in:
  1. Vasoactive intestinal polypeptide receptor 1
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Nanobody 35
IPR036284
Domain description: G-protein gamma-like domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR011025
Domain description: G protein alpha subunit, helical insertion
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR017981
Domain description: GPCR, family 2-like, 7TM
Occurring in:
  1. Vasoactive intestinal polypeptide receptor 1
IPR046963
Domain description: VIP/GHRH-like
Occurring in:
  1. Vasoactive intestinal peptide
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Nanobody 35
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Nanobody 35
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Nanobody 35
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Nanobody 35
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR016346
Domain description: Guanine nucleotide-binding protein, beta subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

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