8e4l

Electron Microscopy
3.32Å resolution

The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2

Released:
Source organism: Mus musculus
Related structures: EMD-27891

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
PDBe Complex ID:
PDB-CPX-185896 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1135 amino acids
Theoretical weight: 131.55 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8R4D5 (Residues: 2-1104; Coverage: 100%)
Gene names: Ltrpc6, Trpm8, Trpp8
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.32Å
Relevant EMDB volumes: EMD-27891
Expression system: Homo sapiens