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The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2

Source organism: Mus musculus
Biochemical function: identical protein binding
Biological process: positive regulation of cold-induced thermogenesis
Cellular component: membrane raft

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00520
Domain description: Ion transport protein
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 8
The deposited structure of PDB entry 8e4l contains 4 copies of Pfam domain PF00520 (Ion transport protein) in Transient receptor potential cation channel subfamily M member 8. Showing 1 copy in chain A.

PF18139
Domain description: SLOG in TRPM
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 8
The deposited structure of PDB entry 8e4l contains 4 copies of Pfam domain PF18139 (SLOG in TRPM) in Transient receptor potential cation channel subfamily M member 8. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005821
Domain description: Ion transport domain
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 8
IPR041491
Domain description: TRPM, SLOG domain
Occurring in:
  1. Transient receptor potential cation channel subfamily M member 8

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