› › Function and Biology

Human Adenosine Deaminase Acting on dsRNA (ADAR2-R2D) bound to dsRNA containing a G:3-deaza dA pair adjacent to the target site

Source organism: Homo sapiens
Biochemical function: adenosine deaminase activity
Biological process: RNA processing
Cellular component: not assigned

Quick links

EC 3.5.4.37: Double-stranded RNA adenine deaminase

Reaction catalysed:
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3)
Systematic name:
Double-stranded RNA adenine aminohydrolase
Alternative Name(s):
  • ADAR
  • DRADA1
  • Double-stranded RNA adenosine deaminase
  • Double-stranded RNA-specific adenosine deaminase
  • DsRAD
  • DsRNA adenosine deaminase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02137
Domain description: Adenosine-deaminase (editase) domain
Occurring in:
  1. Double-stranded RNA-specific editase 1
The deposited structure of PDB entry 8e4x contains 2 copies of Pfam domain PF02137 (Adenosine-deaminase (editase) domain) in Double-stranded RNA-specific editase 1. Showing 1 copy in chain B.

PF00035
Domain description: Double-stranded RNA binding motif
Occurring in:
  1. Double-stranded RNA-specific editase 1
The deposited structure of PDB entry 8e4x contains 2 copies of Pfam domain PF00035 (Double-stranded RNA binding motif) in Double-stranded RNA-specific editase 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002466
Domain description: Adenosine deaminase/editase
Occurring in:
  1. Double-stranded RNA-specific editase 1
IPR014720
Domain description: Double-stranded RNA-binding domain
Occurring in:
  1. Double-stranded RNA-specific editase 1
IPR008996
Domain description: Cytokine IL1/FGF
Occurring in:
  1. Double-stranded RNA-specific editase 1
IPR044459
Domain description: ADAR2, second double-stranded RNA binding domain
Occurring in:
  1. Double-stranded RNA-specific editase 1

Quick links