› 8e7j

Electron Microscopy
3.1Å resolution

Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient

Released:
DOI: 10.2210/pdb8e7j/pdb
PDB entry 8e7j coloured by chain, front view.
PDB entry 8e7j coloured by chain, side view.
PDB entry 8e7j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy.
Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, Pękała M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L
Nat Commun 15 581 (2024)
PMID: 38233397
Related structures: EMD-27323

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-227647 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 147 amino acids
Theoretical weight: 15.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 1-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-27323

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