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D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation

Electron Microscopy
3.75Å resolution
PDB entry 8e98 coloured by chain, front view.
PDB entry 8e98 coloured by chain, side view.
PDB entry 8e98 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NMDA receptor complex, GluN1-GluN2C
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Multimeric state: hetero tetramer
Accessible surface area: 127196.54 Å2
Buried surface area: 11067.13 Å2
Dissociation area: 1,733.74 Å2
Dissociation energy (ΔGdiss): 8.36 kcal/mol
Dissociation entropy (TΔSdiss): 16.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-274454
Complex Portal ID: CPX-286

Macromolecules

Glutamate receptor ionotropic, NMDA 1
Chains: A, C
Length: 847 amino acids
Theoretical weight: 95.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05586 (Residues: 1-847; Coverage: 90%)
Gene names: GRIN1, NMDAR1
Pfam:
InterPro:
Glutamate receptor ionotropic, NMDA 1 in PDB entry 8e98, assembly 1, front view.
Glutamate receptor ionotropic, NMDA 1 in PDB entry 8e98, assembly 1, side view.
Glutamate receptor ionotropic, NMDA 1 in PDB entry 8e98, assembly 1, top view.
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Glutamate receptor ionotropic, NMDA 2C
Chains: B, D
Length: 880 amino acids
Theoretical weight: 96.96 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14957 (Residues: 26-849; Coverage: 68%)
Gene names: GRIN2C, NMDAR2C
Pfam:
InterPro:
Glutamate receptor ionotropic, NMDA 2C in PDB entry 8e98, assembly 1, front view.
Glutamate receptor ionotropic, NMDA 2C in PDB entry 8e98, assembly 1, side view.
Glutamate receptor ionotropic, NMDA 2C in PDB entry 8e98, assembly 1, top view.
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