› 8ear

Electron Microscopy
3.5Å resolution

Structure of the full-length IP3R1 channel determined in the presence of Calcium/IP3/ATP

Released:
DOI: 10.2210/pdb8ear/pdb
PDB entry 8ear coloured by chain, front view.
PDB entry 8ear coloured by chain, side view.
PDB entry 8ear coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Conformational motions and ligand-binding underlying gating and regulation in IP3R channel.
Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II
OpenAccess logo Nat Commun 13 6942 (2022)
PMID: 36376291
Related structures: EMD-27983

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 2750 amino acids
Theoretical weight: 313.66 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P29994 (Residues: 1-2750; Coverage: 100%)
Gene names: Insp3r, Itpr1
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand ZN 4 x ZN
Ligand ATP 4 x ATP
Ligand I3P 4 x I3P
Ligand CA 16 x CA
Ligand PLX 28 x PLX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-27983

Quick links

Citations

3 review citations

Ca2+ Signaling and Src Functions in Tumor Cells.
Villalobo A. (2023)
2 more

1 mention without citation

Conformational motions and ligand-binding underlying gating and regulation in IP3R channel.
Fan et al. (2022)