› 8ed9

Electron Microscopy
3.4Å resolution

cryo-EM structure of TRPM3 ion channel in the presence with PIP2 and PregS, state 2

Released:
DOI: 10.2210/pdb8ed9/pdb
PDB entry 8ed9 coloured by chain, front view.
PDB entry 8ed9 coloured by chain, side view.
PDB entry 8ed9 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Zhao C, MacKinnon R
Neuron (2022)
PMID: 36283409
Related structures: EMD-28033

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271353 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transient receptor potential cation channel subfamily M member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1343 amino acids
Theoretical weight: 154.65 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: J9SQF3 (Residues: 52-1367; Coverage: 75%)
Gene name: Trpm3
Sequence domains:
Unidentified segment at the N-terminus of TRPM3 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 17 amino acids
Theoretical weight: 1.46 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

4 bound ligands:
Ligand 3PH 4 x 3PH
Ligand 9Z9 4 x 9Z9
Ligand PIO 4 x PIO
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-28033
Expression system: Homo sapiens

Quick links

Citations

4 review citations

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases.
Zhang et al. (2023)
3 more