8ef5

Electron Microscopy
3.3Å resolution

Fentanyl-bound mu-opioid receptor-Gi complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-273605 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Mu-type opioid receptor Chains: M, R
Molecule details ›
Chains: M, R
Length: 367 amino acids
Theoretical weight: 41.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chains: A, F
Molecule details ›
Chains: A, F
Length: 354 amino acids
Theoretical weight: 40.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
scFv16 Chain: E

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-28066
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli