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Cryo-EM structure of the active NLRP3 inflammasome disk

Source organism: Homo sapiens
Biochemical function: molecular function activator activity
Biological process: positive regulation of NLRP3 inflammasome complex assembly
Cellular component: microtubule

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF13516
Domain description: Leucine Rich repeat
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
The deposited structure of PDB entry 8ej4 contains 30 copies of Pfam domain PF13516 (Leucine Rich repeat) in NACHT, LRR and PYD domains-containing protein 3. Showing 3 copies in chain A.

PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Serine/threonine-protein kinase Nek7
The deposited structure of PDB entry 8ej4 contains 10 copies of Pfam domain PF00069 (Protein kinase domain) in Serine/threonine-protein kinase Nek7. Showing 1 copy in chain K.

PF17776
Domain description: NLRC4 helical domain HD2
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
The deposited structure of PDB entry 8ej4 contains 10 copies of Pfam domain PF17776 (NLRC4 helical domain HD2) in NACHT, LRR and PYD domains-containing protein 3. Showing 1 copy in chain A.

PF17779
Domain description: NOD2 winged helix domain
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
The deposited structure of PDB entry 8ej4 contains 10 copies of Pfam domain PF17779 (NOD2 winged helix domain) in NACHT, LRR and PYD domains-containing protein 3. Showing 1 copy in chain A.

PF05729
Domain description: NACHT domain
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
The deposited structure of PDB entry 8ej4 contains 10 copies of Pfam domain PF05729 (NACHT domain) in NACHT, LRR and PYD domains-containing protein 3. Showing 1 copy in chain A.

PF14484
Domain description: Fish-specific NACHT associated domain
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
The deposited structure of PDB entry 8ej4 contains 10 copies of Pfam domain PF14484 (Fish-specific NACHT associated domain) in NACHT, LRR and PYD domains-containing protein 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001611
Domain description: Leucine-rich repeat
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
IPR001245
Domain description: Serine-threonine/tyrosine-protein kinase, catalytic domain
Occurring in:
  1. Serine/threonine-protein kinase Nek7
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Serine/threonine-protein kinase Nek7
IPR007111
Domain description: NACHT nucleoside triphosphatase
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
IPR029495
Domain description: NACHT-associated domain
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Serine/threonine-protein kinase Nek7
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Serine/threonine-protein kinase Nek7
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Serine/threonine-protein kinase Nek7
IPR032675
Domain description: Leucine-rich repeat domain superfamily
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
IPR041267
Domain description: NACHT, LRR and PYD domains-containing protein, helical domain HD2
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3
IPR041075
Domain description: NOD1/2, winged helix domain
Occurring in:
  1. NACHT, LRR and PYD domains-containing protein 3

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