› 8ejs

X-ray diffraction
2.82Å resolution

Kelch domain of human KEAP1 bound to Nrf2 linear peptide, Ac-(BAla)DPETGE-NH2

Released:
DOI: 10.2210/pdb8ejs/pdb
PDB entry 8ejs coloured by chain, front view.
PDB entry 8ejs coloured by chain, side view.
PDB entry 8ejs coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Muellers SN, Allen KN

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171935 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kelch-like ECH-associated protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 336 amino acids
Theoretical weight: 36.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14145 (Residues: 312-624; Coverage: 50%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: Kelch motif
Nuclear factor erythroid 2-related factor 2 Chain: C
Molecule details ›
Chain: C
Length: 8 amino acids
Theoretical weight: 716 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16236 (Residues: 76-82; Coverage: 1%)
Gene names: NFE2L2, NRF2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Unit cell:
a: 77.69Å b: 68.908Å c: 144.092Å
α: 90° β: 90.851° γ: 90°
R-values:
R R work R free
0.219 0.217 0.266
Expression systems:
  • Escherichia coli
  • Not provided

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