› 8em2

Electron Microscopy
3.02Å resolution

Cryo-EM structure of the human GDH/6PGL endoplasmic bifunctional protein

Released:
DOI: 10.2210/pdb8em2/pdb
PDB entry 8em2 coloured by chain, front view.
PDB entry 8em2 coloured by chain, side view.
PDB entry 8em2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structural-omics of human liver enzymes.
Su CC, Lyu M, Zhang Z, Miyagi M, Huang W, Taylor DJ, Yu EW
OpenAccess logo Cell Rep 42 112609 (2023)
PMID: 37289586
Related structures: EMD-23429, EMD-28232

Function and Biology Details

Reactions catalysed: 
D-glucose 6-phosphate + NAD(P)(+) = 6-phospho-D-glucono-1,5-lactone + NAD(P)H
D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H
6-phospho-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215127 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GDH/6PGL endoplasmic bifunctional protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 791 amino acids
Theoretical weight: 89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95479 (Residues: 1-791; Coverage: 100%)
Gene names: GDH, H6PD
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.02Å
Relevant EMDB volumes: EMD-23429, EMD-28232

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Citations

1 citations in other articles

High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Zhang et al. (2023)