› 8epa

Electron Microscopy
3.4Å resolution

Structure of interleukin receptor common gamma chain (IL2Rgamma) in complex with two antibodies

Released:
DOI: 10.2210/pdb8epa/pdb
PDB entry 8epa coloured by chain, front view.
PDB entry 8epa coloured by chain, side view.
PDB entry 8epa coloured by chain, top view.
Source organisms:
Primary publication:
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.
Le Floc'h A, Nagashima K, Birchard D, Scott G, Ben LH, Ajithdoss D, Gayvert K, Romero Hernandez A, Herbin O, Tay A, Farrales P, Korgaonkar CK, Pan H, Shah S, Kamat V, Chatterjee I, Popke J, Oyejide A, Lim WK, Kim JH, Huang T, Franklin M, Olson W, Norton T, Perlee L, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM
Sci Transl Med 15 eabo0205 (2023)
PMID: 36630481
Related structures: EMD-28523

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225592 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
Cytokine receptor common subunit gamma Chain: I
Molecule details ›
Chain: I
Length: 268 amino acids
Theoretical weight: 31.62 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P31785 (Residues: 23-262; Coverage: 69%)
Gene name: IL2RG
Sequence domains:
REGN7257 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 220 amino acids
Theoretical weight: 23.61 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
REGN7257 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.54 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
REGN9432 Fab heavy chain Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 23.32 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
REGN9432 Fab light chain Chain: B
Molecule details ›
Chain: B
Length: 214 amino acids
Theoretical weight: 23.25 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Ligand NAG 2 x NAG
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-28523
Expression system: Cricetulus griseus

Quick links

Citations

1 review citation

Strategies to therapeutically modulate cytokine action.
Leonard et al. (2023)
2 other articles