› 8eqf

Electron Microscopy
3.16Å resolution

cryoEM structure of a broadly neutralizing anti-SARS-CoV-2 antibody STI-9167

Released:
DOI: 10.2210/pdb8eqf/pdb
PDB entry 8eqf coloured by chain, front view.
PDB entry 8eqf coloured by chain, side view.
PDB entry 8eqf coloured by chain, top view.
Source organisms:
Primary publication:
An in vitro experimental pipeline to characterize the epitope of a SARS-CoV-2 neutralizing antibody.
Atanasoff KE, Brambilla L, Adelsberg DC, Kowdle S, Stevens CS, Slamanig S, Hung C-T, Fu Y, Lim R, Tran L, Allen R, Sun W, Duty JA, Bajic G, Lee B, Tortorella D
OpenAccess logo mBio 15 e0247723 (2024)
PMID: 38054729
Related structures: EMD-28537

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-535114 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike protein S1 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 21.78 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 333-526; Coverage: 15%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 123 amino acids
Theoretical weight: 13.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 107 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.16Å
Relevant EMDB volumes: EMD-28537
Expression system: Homo sapiens

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