› 8er6

X-ray diffraction
2.81Å resolution

Function and Biology Details

Reactions catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154618 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase FKBP1A Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62942 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP1, FKBP12, FKBP1A
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Serine/threonine-protein kinase mTOR Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 95 amino acids
Theoretical weight: 11.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42345 (Residues: 2019-2112; Coverage: 4%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Sequence domains: FKBP12-rapamycin binding domain

Ligands and Environments

2 bound ligands:
Ligand XYU 3 x XYU
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P6422
Unit cell:
a: 125.309Å b: 125.309Å c: 252.851Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.201 0.224
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis.
Evans et al. (2023)
2 more

1 mention without citation

Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
Burnett et al. (2023)