› 8erc

Electron Microscopy
3.7Å resolution

Human Membrane-bound O-acyltransferase 7

Released:
DOI: 10.2210/pdb8erc/pdb
PDB entry 8erc coloured by chain, front view.
PDB entry 8erc coloured by chain, side view.
PDB entry 8erc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification.
Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Liao M, Walther TC, Farese RV
Nat Commun 14 3533 (2023)
PMID: 37316513
Related structures: EMD-28552

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysophospholipid acyltransferase 7 Chain: A
Molecule details ›
Chain: A
Length: 484 amino acids
Theoretical weight: 54.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96N66 (Residues: 1-472; Coverage: 100%)
Gene names: BB1, LENG4, MBOAT7, OACT7
Sequence domains: MBOAT, membrane-bound O-acyltransferase family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-28552
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Liver Involvement in Patients with Rare MBOAT7 Variants and Intellectual Disability: A Case Report and Literature Review.
Ronzoni et al. (2023)
1 other article