› 8et1

Electron Microscopy
4.48Å resolution

CryoEM structure of GSDMB pore without transmembrane beta-barrel

Released:
DOI: 10.2210/pdb8et1/pdb
PDB entry 8et1 coloured by chain, front view.
PDB entry 8et1 coloured by chain, side view.
PDB entry 8et1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
Wang C, Shivcharan S, Tian T, Wright S, Ma D, Chang J, Li K, Song K, Xu C, Rathinam VA, Ruan J
OpenAccess logo Nature (2023)
PMID: 36991122
Related structures: EMD-28583

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215252 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gasdermin-B Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X
Length: 411 amino acids
Theoretical weight: 46.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TAX9 (Residues: 1-220, 221-416; Coverage: 98%)
  • Best match: Q8TAX9-1 (Residues: 1-411)
Gene names: GSDMB, GSDML, PP4052, PRO2521
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4.48Å
Relevant EMDB volumes: EMD-28583
Expression system: Escherichia coli

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Citations

10 review citations

Ubiquitin-targeted bacterial effectors: rule breakers of the ubiquitin system.
Roberts et al. (2023)
9 more