Function and Biology

Class1 of the INO80-Hexasome complex

Source organism: Saccharomyces cerevisiae S288C
Biochemical function: 5'-3' DNA helicase activity
Biological process: chromatin remodeling
Cellular component: Ino80 complex

EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

Sequence families

Pfam Protein families (Pfam)
PF17856
Domain description: TIP49 AAA-lid domain
Occurring in:
  1. RuvB-like protein 1
  2. RuvB-like protein 2
The deposited structure of PDB entry 8ets contains 3 copies of Pfam domain PF17856 (TIP49 AAA-lid domain) in RuvB-like protein 1. Showing 1 copy in chain F [auth V].
The deposited structure of PDB entry 8ets contains 3 copies of Pfam domain PF17856 (TIP49 AAA-lid domain) in RuvB-like protein 2. Showing 1 copy in chain I [auth Y].

PF06068
Domain description: TIP49 P-loop domain
Occurring in:
  1. RuvB-like protein 1
  2. RuvB-like protein 2
The deposited structure of PDB entry 8ets contains 3 copies of Pfam domain PF06068 (TIP49 P-loop domain) in RuvB-like protein 1. Showing 1 copy in chain F [auth V].
The deposited structure of PDB entry 8ets contains 3 copies of Pfam domain PF06068 (TIP49 P-loop domain) in RuvB-like protein 2. Showing 1 copy in chain I [auth Y].

PF00022
Domain description: Actin
Occurring in:
  1. Actin-related protein 5
The deposited structure of PDB entry 8ets contains 2 copies of Pfam domain PF00022 (Actin) in Actin-related protein 5. Showing 2 copies in chain B [auth R].

PF04795
Domain description: PAPA-1-like conserved region
Occurring in:
  1. Ino eighty subunit 2
The deposited structure of PDB entry 8ets contains 1 copy of Pfam domain PF04795 (PAPA-1-like conserved region) in Ino eighty subunit 2. Showing 1 copy in chain J [auth Z].

PF08265
Domain description: YL1 nuclear protein C-terminal domain
Occurring in:
  1. Chromatin-remodeling complex subunit IES6
The deposited structure of PDB entry 8ets contains 1 copy of Pfam domain PF08265 (YL1 nuclear protein C-terminal domain) in Chromatin-remodeling complex subunit IES6. Showing 1 copy in chain C [auth S].

PF00271
Domain description: Helicase conserved C-terminal domain
Occurring in:
  1. Chromatin-remodeling ATPase INO80
The deposited structure of PDB entry 8ets contains 1 copy of Pfam domain PF00271 (Helicase conserved C-terminal domain) in Chromatin-remodeling ATPase INO80. Showing 1 copy in chain A [auth Q].