Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Serine-threonine/tyrosine-protein kinase, catalytic domain
- Tyrosine-protein kinase, non-receptor Jak1
- Tyrosine-protein kinase, non-receptor Jak/Tyk2
- Tyrosine-protein kinase, catalytic domain
- Protein kinase domain
- Protein kinase-like domain superfamily
- SH2 domain
- SH2 domain superfamily
10 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246324 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase JAK1
Molecule details ›
Chains: A, B
Length: 1173 amino acids
Theoretical weight: 136.03 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 1173 amino acids
Theoretical weight: 136.03 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P52332 (Residues: 1-261, 262-1153; Coverage: 100%)
Sequence domains:
General control transcription factor GCN4; Interferon lambda receptor 1
Molecule details ›
