› 8eze

Electron Microscopy
2.76Å resolution

Brain-derived 42-residue amyloid-beta fibril type B

Released:
DOI: 10.2210/pdb8eze/pdb
PDB entry 8eze coloured by chain, ensemble of 9 models, front view.
PDB entry 8eze coloured by chain, ensemble of 9 models, side view.
PDB entry 8eze coloured by chain, ensemble of 9 models, top view.
Source organism: Homo sapiens
Primary publication:
Structures of brain-derived 42-residue amyloid-β fibril polymorphs with unusual molecular conformations and intermolecular interactions.
Lee M, Yau WM, Louis JM, Tycko R
OpenAccess logo Proc Natl Acad Sci U S A 120 e2218831120 (2023)
PMID: 36893281
Related structures: EMD-28741

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138403 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 42 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 42 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05067 (Residues: 672-713; Coverage: 6%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.76Å
Relevant EMDB volumes: EMD-28741
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer's Disease.
Nguyen et al. (2023)
4 other articles