8f0h

Electron Microscopy
3.18Å resolution

Structure of SARS-CoV-2 spike with antibody Fabs 2A10 and 1H2 (Local refinement of the RBD and Fabs 1H2 and 2A10)

Released:

Function and Biology Details

Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-225326 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
Antibody Fab 1H2 heavy chain Chain: B
Molecule details ›
Chain: B
Length: 124 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Spike glycoprotein Chain: C
Molecule details ›
Chain: C
Length: 1212 amino acids
Theoretical weight: 134.07 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P0DTC2 (Residues: 14-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
Antibody Fab 1H2 light chain Chain: D
Molecule details ›
Chain: D
Length: 101 amino acids
Theoretical weight: 10.8 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Antibody Fab 2A10 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 115 amino acids
Theoretical weight: 12.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Antibody Fab 2A10 light chain Chain: L
Molecule details ›
Chain: L
Length: 109 amino acids
Theoretical weight: 11.92 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.18Å
Relevant EMDB volumes: EMD-28757
Expression system: Cricetulus griseus