› 8f0i

X-ray diffraction
3.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272902 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike protein S1 Chains: A, B, G
Molecule details ›
Chains: A, B, G
Length: 205 amino acids
Theoretical weight: 23.1 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P0DTC2 (Residues: 333-530; Coverage: 16%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
COVA309-22 heavy chain Chains: C, E, H
Molecule details ›
Chains: C, E, H
Length: 223 amino acids
Theoretical weight: 23.92 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
COVA309-22 light chain Chains: D, F, I
Molecule details ›
Chains: D, F, I
Length: 216 amino acids
Theoretical weight: 23.57 KDa
Source organism: Homo sapiens
Expression system: Mus musculus

Ligands and Environments

1 bound ligand:
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 54.725Å b: 152.53Å c: 240.786Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.226 0.275
Expression systems:
  • Trichoplusia ni
  • Mus musculus

Quick links

Citations

1 review citation

Function and mechanism of bispecific antibodies targeting SARS-CoV-2.
Li et al. (2024)
3 other articles

1 mention without citation

Broad SARS-CoV-2 neutralization by monoclonal and bispecific antibodies derived from a Gamma-infected individual.
Guerra et al. (2023)