PDB 8f0j structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

protein binding

Biological process:

G protein-coupled receptor signaling pathway

Cellular component:

membrane

Structure analysis Details

Assembly composition:

hetero hexamer (preferred)

PDBe Complex ID:

PDB-CPX-273153 (preferred)

Entry contents:

6 distinct polypeptide molecules

Macromolecules (6 distinct):

Islet amyloid polypeptide Chain: P

Molecule details ›

Chain: P
Length: 38 amino acids
Theoretical weight: 3.97 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:

Canonical: P10997 (Residues: 34-70; Coverage: 55%)

Gene name: IAPP
Sequence domains: Calcitonin / CGRP / IAPP family

Calcitonin receptor Chain: R

Molecule details ›

Chain: R
Length: 501 amino acids
Theoretical weight: 58.47 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:

Canonical: P30988 (Residues: 25-474; Coverage: 100%)
Best match: P30988-3 (Residues: 1-427)

Gene name: CALCR
Sequence domains:

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A

Molecule details ›

Chain: A
Length: 394 amino acids
Theoretical weight: 45.68 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:

Canonical: P63092 (Residues: 1-394; Coverage: 100%)
Best match: P63092-4 (Residues: 1-395)

Gene names: GNAS, GNAS1, GSP
Sequence domains: G-protein alpha subunit

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B

Molecule details ›

Chain: B
Length: 350 amino acids
Theoretical weight: 38.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:

Canonical: P62873 (Residues: 2-340; Coverage: 100%)

Gene name: GNB1
Sequence domains: WD domain, G-beta repeat

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G

Molecule details ›

Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt: