› 8f1z

X-ray diffraction
2.4Å resolution

EGFR kinase in complex with Bayer #33

Released:
DOI: 10.2210/pdb8f1z/pdb
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PDB entry 8f1z coloured by chain, front view.
PDB entry 8f1z coloured by chain, side view.
PDB entry 8f1z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity.
Zhao H, Beyett TS, Jiang J, Rana JK, Schaeffner IK, Santana J, Jänne PA, Eck MJ
Proc Natl Acad Sci U S A 121 e2417144121 (2024)
PMID: 39471218

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 695-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

2 bound ligands:
Ligand X9B 1 x X9B
Ligand CIT 2 x CIT
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: I23
Unit cell:
a: 146.131Å b: 146.131Å c: 146.131Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.212
Expression system: Spodoptera frugiperda

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