EC 1.14.99.66: [Histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + acceptor + H(2)O = a [histone H3]-N(6)-methyl-L-lysine(4) + formaldehyde + reduced acceptor
Systematic name:
[Histone H3]-N(6),N(6)-dimethyl-L-lysine(4):acceptor oxidoreductase (demethylating)
Alternative Name(s):
- Lysine-specific histone demethylase 1
GO terms
Biochemical function:
- promoter-specific chromatin binding
- FAD-dependent H3K4me/H3K4me3 demethylase activity
- DNA-binding transcription factor binding
- telomeric repeat-containing RNA binding
- RNA polymerase II-specific DNA-binding transcription factor binding
- nuclear androgen receptor binding
- flavin adenine dinucleotide binding
- MRF binding
- identical protein binding
- telomeric DNA binding
- histone H3K9 demethylase activity
- histone H3K4 demethylase activity
- histone demethylase activity
- demethylase activity
- nuclear receptor coactivator activity
- enzyme binding
- oxidoreductase activity
- protein binding
- transcription coactivator activity
- chromatin binding
- p53 binding
Biological process:
- positive regulation of stem cell proliferation
- positive regulation of neural precursor cell proliferation
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- DNA repair-dependent chromatin remodeling
- positive regulation of cold-induced thermogenesis
- regulation of DNA methylation-dependent heterochromatin formation
- cellular response to gamma radiation
- cellular response to cAMP
- response to fungicide
- regulation of androgen receptor signaling pathway
- muscle cell development
- guanine metabolic process
- positive regulation of transcription by RNA polymerase II
- negative regulation of DNA-templated transcription
- positive regulation of cell size
- negative regulation of DNA damage response, signal transduction by p53 class mediator
- negative regulation of DNA-binding transcription factor activity
- negative regulation of DNA binding
- neuron maturation
- protein modification process
- cellular response to UV
- regulation of protein localization
- negative regulation of protein binding
- positive regulation of protein ubiquitination
- cerebral cortex development
- response to organic cyclic compound
- positive regulation of neuron projection development
- positive regulation of epithelial to mesenchymal transition
- regulation of double-strand break repair via homologous recombination
- protein demethylation
- regulation of transcription by RNA polymerase II
- chromatin remodeling
- chromatin organization
- positive regulation of neuroblast proliferation
- negative regulation of transcription by RNA polymerase II
Protein families (Pfam)