› 8f4v

Solution NMR

Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state

Released:
DOI: 10.2210/pdb8f4v/pdb
PDB entry 8f4v coloured by chain, ensemble of 15 models, front view.
PDB entry 8f4v coloured by chain, ensemble of 15 models, side view.
PDB entry 8f4v coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization.
Bondarenko V, Chen Q, Singewald K, Haloi N, Tillman TS, Howard RJ, Lindahl E, Xu Y, Tang P
OpenAccess logo ACS Chem Neurosci (2023)
PMID: 36821490

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153193 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuronal acetylcholine receptor subunit alpha-7 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 272 amino acids
Theoretical weight: 29.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P36544 (Residues: 231-496; Coverage: 55%)
Gene names: CHRNA7, NACHRA7
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region

Ligands and Environments

1 bound ligand:
Ligand IVM 5 x IVM
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 12%
Refinement method: na
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation.
Burke et al. (2024)

1 mention without citation

Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization.
Bondarenko et al. (2023)