› 8f53

Electron Microscopy
2.93Å resolution

Top-down design of protein architectures with reinforcement learning

Released:
DOI: 10.2210/pdb8f53/pdb
PDB entry 8f53 coloured by chain, front view.
PDB entry 8f53 coloured by chain, side view.
PDB entry 8f53 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Top-down design of protein architectures with reinforcement learning.
Lutz ID, Wang S, Norn C, Courbet A, Borst AJ, Zhao YT, Dosey A, Cao L, Xu J, Leaf EM, Treichel C, Litvicov P, Li Z, Goodson AD, Rivera-Sánchez P, Bratovianu AM, Baek M, King NP, Ruohola-Baker H, Baker D
Science 380 266-273 (2023)
PMID: 37079676
Related structures: EMD-28859

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215488 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RC_I_2 Chains: 0, 2, A, Ae, B, Ba, Bb, C, Ca, Cz, D, Dc, Dy, E, Ex, F, Fg, Fw, G, Gf, Gv, H, He, Hu, I, Id, J, J1, K, Kk, L, Lj, M, Mi, N, Nh, O, Od, P, Po, Q, Qn, R, Rm, S, Sl, T, Tc, U, Us, V, Vr, W, Wq, X, Xp, Y, Yb, Z, Zt
Molecule details ›
Chains: 0, 2, A, Ae, B, Ba, Bb, C, Ca, Cz, D, Dc, Dy, E, Ex, F, Fg, Fw, G, Gf, Gv, H, He, Hu, I, Id, J, J1, K, Kk, L, Lj, M, Mi, N, Nh, O, Od, P, Po, Q, Qn, R, Rm, S, Sl, T, Tc, U, Us, V, Vr, W, Wq, X, Xp, Y, Yb, Z, Zt
Length: 54 amino acids
Theoretical weight: 5.89 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.93Å
Relevant EMDB volumes: EMD-28859
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Machine Learning-Guided Protein Engineering.
Kouba et al. (2023)
4 more