› 8f59

X-ray diffraction
2.8Å resolution

LSD1-CoREST in complex with AW2 and SNAG peptide

Released:
DOI: 10.2210/pdb8f59/pdb
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PDB entry 8f59 coloured by chain, front view.
PDB entry 8f59 coloured by chain, side view.
PDB entry 8f59 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Caroli J, Mattevi A

Function and Biology Details

Reaction catalysed: 
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + acceptor + H(2)O = a [histone H3]-N(6)-methyl-L-lysine(4) + formaldehyde + reduced acceptor
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-129947 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Lysine-specific histone demethylase 1A Chain: A
Molecule details ›
Chain: A
Length: 871 amino acids
Theoretical weight: 95.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60341 (Residues: 1-852; Coverage: 100%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Sequence domains:
REST corepressor 1 Chain: B
Molecule details ›
Chain: B
Length: 144 amino acids
Theoretical weight: 16.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKL0 (Residues: 308-443; Coverage: 28%)
Gene names: KIAA0071, RCOR, RCOR1
Sequence domains:
Zinc finger protein SNAI1 Chain: C

Ligands and Environments

1 bound ligand:
Ligand XB6 1 x XB6
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: I222
Unit cell:
a: 120.206Å b: 179.201Å c: 236.155Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.234
Expression systems:
  • Escherichia coli
  • Not provided

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