› 8f5t

X-ray diffraction
2.41Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + pyruvate = ADP + phosphoenolpyruvate
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146016 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyruvate kinase PKM Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 531 amino acids
Theoretical weight: 58.11 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P11974 (Residues: 1-531; Coverage: 100%)
Gene name: PKM
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand MG 8 x MG
Ligand NA 8 x NA
Ligand TRS 6 x TRS
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P21
Unit cell:
a: 142.453Å b: 113.759Å c: 169.144Å
α: 90° β: 94.05° γ: 90°
R-values:
R R work R free
0.187 0.185 0.232

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