› 8f6l

X-ray diffraction
1.85Å resolution

anti-BTLA monoclonal antibody h25F7 in complex with BTLA

Released:
DOI: 10.2210/pdb8f6l/pdb
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PDB entry 8f6l coloured by chain, front view.
PDB entry 8f6l coloured by chain, side view.
PDB entry 8f6l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA.
Cheung TC, Atwell S, Bafetti L, Cuenca PD, Froning K, Hendle J, Hickey M, Ho C, Huang J, Lieu R, Lim S, Lippner D, Obungu V, Ward-Kavanagh L, Weichert K, Ware CF, Vendel AC
Structure (2023)
PMID: 37279757

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-280260 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
h25F7 Fab heavy chain Chain: A
Molecule details ›
Chain: A
Length: 235 amino acids
Theoretical weight: 25.04 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
h25F7 Fab light chain Chain: B
Molecule details ›
Chain: B
Length: 217 amino acids
Theoretical weight: 23.51 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
B- and T-lymphocyte attenuator Chain: C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P212121
Unit cell:
a: 48.961Å b: 68.6Å c: 187.321Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.24
Expression system: Cricetulus griseus

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