› 8f7r

Electron Microscopy
3.28Å resolution

Gi bound mu-opioid receptor in complex with endomorphin

Released:
DOI: 10.2210/pdb8f7r/pdb
PDB entry 8f7r coloured by chain, front view.
PDB entry 8f7r coloured by chain, side view.
PDB entry 8f7r coloured by chain, top view.
Source organisms:
Primary publication:
Structures of the entire human opioid receptor family.
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023)
PMID: 36638794
Related structures: EMD-28908

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
PDBe Complex ID:
PDB-CPX-273604 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Mu-type opioid receptor Chains: M, R
Molecule details ›
Chains: M, R
Length: 403 amino acids
Theoretical weight: 45.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
endomorphin Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 5 amino acids
Theoretical weight: 610 Da
Source organism: Homo sapiens
Expression system: Not provided
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chains: A, F
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
scFv16 Chain: E

Ligands and Environments

1 bound ligand:
Ligand CLR 10 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.28Å
Relevant EMDB volumes: EMD-28908
Expression systems:
  • Spodoptera frugiperda
  • Not provided
  • Escherichia coli

Quick links

Citations

13 review citations

Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport.
Mazzeo et al. (2023)
12 more

4 mentions without citation

Structure-Activity Relationship Target Prediction Studies of Clindamycin Derivatives with Broad-Spectrum Bacteriostatic Antibacterial Properties.
Jia et al. (2023)
3 more