› 8f8l

X-ray diffraction
2.2Å resolution

The structure of Rv2173 from M. tuberculosis with DMAP bound

Released:
DOI: 10.2210/pdb8f8l/pdb
PDB entry 8f8l coloured by chain, front view.
PDB entry 8f8l coloured by chain, side view.
PDB entry 8f8l coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Entry authors: Johnston JM, Allison TM, Titterington J

Function and Biology Details

Reactions catalysed: 
Prenyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236058 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
(2E,6E)-farnesyl diphosphate synthase Chain: A
Molecule details ›
Chain: A
Length: 387 amino acids
Theoretical weight: 41.98 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O53507 (Residues: 1-352; Coverage: 100%)
Gene names: Rv2173, idsA2
Sequence domains: Polyprenyl synthetase

Ligands and Environments

3 bound ligands:
Ligand DMA 1 x DMA
Ligand GOL 1 x GOL
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: I222
Unit cell:
a: 66.841Å b: 83.844Å c: 188.122Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.211 0.244
Expression system: Escherichia coli BL21(DE3)

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