› 8f8p

Electron Microscopy
2.26Å resolution

Cryo-EM structure of F-actin in the ADP state

Released:
DOI: 10.2210/pdb8f8p/pdb
PDB entry 8f8p coloured by chain, front view.
PDB entry 8f8p coloured by chain, side view.
PDB entry 8f8p coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structures of the free and capped ends of the actin filament.
Carman PJ, Barrie KR, Rebowski G, Dominguez R
Science eadg6812 (2023)
PMID: 37228182
Related structures: EMD-28932

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159326 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 377 amino acids
Theoretical weight: 42.11 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 1-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin

Ligands and Environments

2 bound ligands:
Ligand ADP 5 x ADP
Ligand MG 5 x MG
1 modified residue:
Ligand HIC 5 x HIC

Experiments and Validation Details

Entry percentile scores
Resolution: 2.26Å
Relevant EMDB volumes: EMD-28932

Quick links

Citations

1 review citation

Mechanisms of actin disassembly and turnover.
Goode et al. (2023)
5 other articles