› 8f9f

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-539207 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ky15.2 Antibody, heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 226 amino acids
Theoretical weight: 24.14 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Ky15.2 Antibody, light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 213 amino acids
Theoretical weight: 23.37 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Circumsporozoite protein Chains: C, P
Molecule details ›
Chains: C, P
Length: 12 amino acids
Theoretical weight: 1.21 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Not provided
UniProt:
  • Canonical: P19597 (Residues: 261-272; Coverage: 3%)
Gene name: CSP

Ligands and Environments

1 bound ligand:
Ligand EDO 13 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 77.372Å b: 86.574Å c: 134.212Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.213 0.24
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

1 review citation

Monoclonal antibodies to the circumsporozoite proteins as an emerging tool for malaria prevention.
Wang et al. (2024)
1 other article

1 mention without citation

Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Thai et al. (2023)