› 8fa8

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-241921 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ky15.11 Antibody, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 232 amino acids
Theoretical weight: 25.17 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Ky15.11 Antibody, light chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.46 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Circumsporozoite protein Chain: P
Molecule details ›
Chain: P
Length: 12 amino acids
Theoretical weight: 1.24 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Not provided
UniProt:
  • Canonical: P19597 (Residues: 193-204; Coverage: 3%)
Gene name: CSP

Ligands and Environments

1 bound ligand:
Ligand EDO 8 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 63.735Å b: 83.149Å c: 92.267Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.201
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

1 citations in other articles

A candidate antibody drug for prevention of malaria.
Williams et al. (2024)

1 mention without citation

Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Thai et al. (2023)