› 8fas

X-ray diffraction
1.55Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-241923 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ky230 Antibody, heavy chain Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 23.75 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Ky230 Antibody, light chain Chain: B
Molecule details ›
Chain: B
Length: 219 amino acids
Theoretical weight: 24.21 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Circumsporozoite protein Chain: C
Molecule details ›
Chain: C
Length: 20 amino acids
Theoretical weight: 2 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Not provided
UniProt:
  • Canonical: P19597 (Residues: 253-272; Coverage: 5%)
Gene name: CSP

Ligands and Environments

1 bound ligand:
Ligand EDO 7 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 54.237Å b: 61.352Å c: 135.532Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.165 0.198
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

1 citations in other articles

A candidate antibody drug for prevention of malaria.
Williams et al. (2024)

1 mention without citation

Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Thai et al. (2023)