› 8fb5

X-ray diffraction
2.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-233994 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ky15.11-SK Antibody, heavy chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 232 amino acids
Theoretical weight: 25.21 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Ky15.11-SK Antibody, light chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 213 amino acids
Theoretical weight: 23.46 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Circumsporozoite protein Chains: I, J, K, O
Molecule details ›
Chains: I, J, K, O
Length: 15 amino acids
Theoretical weight: 1.55 KDa
Source organism: Plasmodium falciparum NF54
Expression system: Not provided
UniProt:
  • Canonical: P19597 (Residues: 95-109; Coverage: 4%)
Gene name: CSP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P2
Unit cell:
a: 95.392Å b: 60.485Å c: 184.907Å
α: 90° β: 98.38° γ: 90°
R-values:
R R work R free
0.25 0.248 0.274
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

1 citations in other articles

A candidate antibody drug for prevention of malaria.
Williams et al. (2024)

1 mention without citation

Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Thai et al. (2023)