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Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 12b

Source organism: Plasmodium vivax Sal-1
Biochemical function: metal ion binding
Biological process: N-terminal peptidyl-glycine N-myristoylation
Cellular component: cytoplasm

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EC 2.3.1.97: Glycylpeptide N-tetradecanoyltransferase

Reaction catalysed:
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Systematic name:
Tetradecanoyl-CoA:N-terminal glycyl-[protein] N-tetradecanoyltransferase
Alternative Name(s):
  • Myristoyl-CoA-protein N-myristoyltransferase
  • Myristoyl-coenzyme A:protein N-myristoyl transferase
  • Myristoylating enzymes
  • NMT (gene name)
  • Peptide N-myristoyltransferase
  • Peptide N-tetradecanoyltransferase
  • Protein N-myristoyltransferase
  • Tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02799
Domain description: Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase
The deposited structure of PDB entry 8fbq contains 1 copy of Pfam domain PF02799 (Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain) in Glycylpeptide N-tetradecanoyltransferase. Showing 1 copy in chain A.

PF01233
Domain description: Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
Occurring in:
  1. Glycylpeptide N-tetradecanoyltransferase
The deposited structure of PDB entry 8fbq contains 1 copy of Pfam domain PF01233 (Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain) in Glycylpeptide N-tetradecanoyltransferase. Showing 1 copy in chain A.

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