8fe9

X-ray diffraction
3.2Å resolution

Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b

Released:
Model geometry
Fit model/data

Function and Biology Details

Reactions catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-170563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activated CDC42 kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 32.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q07912 (Residues: 110-391; Coverage: 27%)
Gene names: ACK1, TNK2
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS-II BEAMLINE 17-ID-1
Spacegroup: I422
Unit cell:
a: 91.69Å b: 91.69Å c: 190.066Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.188 0.228
Expression system: Spodoptera frugiperda