› 8ffl

Electron Microscopy
3.47Å resolution

Wildtype rat TRPV2 in nanodiscs bound to RR

Released:
DOI: 10.2210/pdb8ffl/pdb
PDB entry 8ffl coloured by chain, front view.
PDB entry 8ffl coloured by chain, side view.
PDB entry 8ffl coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular details of ruthenium red pore block in TRPV channels.
Pumroy RA, De Jesús-Pérez JJ, Protopopova AD, Rocereta JA, Fluck EC, Fricke T, Lee BH, Rohacs T, Leffler A, Moiseenkova-Bell V
EMBO Rep (2024)
PMID: 38225355
Related structures: EMD-29046

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 761 amino acids
Theoretical weight: 86.8 KDa
Source organism: Rattus norvegicus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9WUD2 (Residues: 1-761; Coverage: 100%)
Gene names: Sac2b, Trpv2, Vrl1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PEX 4 x PEX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.47Å
Relevant EMDB volumes: EMD-29046
Expression system: Saccharomyces cerevisiae

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