› 8fhs

Electron Microscopy
3.3Å resolution

Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution

Released:
DOI: 10.2210/pdb8fhs/pdb
PDB entry 8fhs coloured by chain, front view.
PDB entry 8fhs coloured by chain, side view.
PDB entry 8fhs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Gao S, Yao X, Chen J, Huang G, Fan X, Xue L, Li Z, Wu T, Zheng Y, Huang J, Jin X, Wang Y, Wang Z, Yu Y, Liu L, Pan X, Song C, Yan N
Cell 186 5363-5374.e16 (2023)
PMID: 37972591
Related structures: EMD-29102

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-236287 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Voltage-dependent L-type calcium channel subunit alpha-1C Chain: A
Molecule details ›
Chain: A
Length: 2221 amino acids
Theoretical weight: 249.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13936 (Residues: 1-2221; Coverage: 100%)
Gene names: CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1
Sequence domains:
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: D
Molecule details ›
Chain: D
Length: 1103 amino acids
Theoretical weight: 124.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54289 (Residues: 1-1103; Coverage: 100%)
Gene names: CACNA2D1, CACNL2A, CCHL2A, MHS3
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-3 Chain: C
Molecule details ›
Chain: C
Length: 484 amino acids
Theoretical weight: 54.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54284 (Residues: 1-484; Coverage: 100%)
Gene names: CACNB3, CACNLB3
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
6 bound ligands:
Ligand CA 2 x CA
Ligand BBI 1 x BBI
Ligand WG6 1 x WG6
Ligand 3PE 2 x 3PE
Ligand CLR 4 x CLR
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-29102
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

Structural biology of voltage-gated calcium channels.
Yao et al. (2024)